The History And Development Of Penicillin

Penicillin has been in existence since the early 1900’s and we have been using it to help treat and cure bacterial infections since then, but it was not developed deliberately. It was actually discovered by accident by a scientist in Scotland named Sir Alexander Fleming in 1928.

While conducting some experiments in his laboratory in London, he noticed that a dish of Staphylococcus had been cross-contaminated with Penicillium notatum. The penicillium inhibited the growth of the bacteria in a semicircle and he believed in the beginning that this was the discovery of a simple disinfectant. He saw that it was effective, but was not very toxic. He did not realize just how important his discovery was at the time and the use of penicillin as a drug did not really start until after 1939. Infectious bacteria was not much of a match for the new drug, but at the time Britain was in the middle of World War II and did not have the money that was required to make the large amount of penicillin that was required in order to do more clinical studies on its usefulness. It soon asked the United States for assistance on the matter.

Soon after a lab in Peoria agreed to assist with the production of the penicillin, a search began to find the most appropriate strain of Penicillium notatum. A strain that multiplied quickly was needed and not too long after a worldwide search began, the strain they were looking for was found in a cantaloupe in a market next to the lab that had agreed to assist the Oxford lab to produce the penicillin in the first place.

By around the end of 1941, a mold nutrition expert named Andrew J. Moyer was able to multiply the production of penicillin by about 10 times and by 1943, penicillin was finally approved by public use. In the beginning, doses of penicillin were very expensive, but as it became more common, the doses went down in price significantly finally settling around fifty cents per dose in the mid 1940’s.

Unfortunately, there are some people that have been found to have an allergic reaction to penicillin and cannot be treated with it in the case of bacterial infection like other people can. If you are allergic to penicillin, it is possible that your child may also be allergic, so if your girlfriend or wife is expecting, you should notify your spouse’s doctor of your allergy.

Mold Causes Valley Fever in the Southwest

There is a mold that exists in the southwestern United States, different areas of South America, and the deserts of Mexico that the majority of people are not aware of when they visit the area. The people the most at risk for coming into contact with this mold are construction workers and archeologists, because they dig around in the soil where this mold tends to be found. What is it called and just how dangerous is it really?

Coccidioides immitis causes a skin disease that has been referred to as “Valley Fever” by some, but as Coccidioidomycosis to physicians. The features of this skin disease are typically rashes, coughing, myalgia, rashes, and headaches. Myalgia is synonymous with “muscle pain” and this can be a sign or symptom of many other different kinds of diseases, not just Valley Fever. The usual cause of myalgia is the over-use of a specific muscle or possibly an entire set of muscles. If a person does not have a medical history of overworking or accidents, then the myalgia is probably being caused by a bacterial or even a viral infection. If it is present in a person chronically, then it could possibly be a sign of some deficiency in the person’s nutrition.

The disease is known to be endemic in the states of New Mexico, California, and Arizona.

The most common cause of C. immitis exposure is due to the digging or disturbing of soil that has been contaminated. For the mold spores to get into the air and allow you to inhale them, this contaminated soil typically needs to be wet and recently, in order for archeologists to be able to dig in soil in the southwestern United States, they have ordered the soil be saturated with water first to avoid this exposure. This has been put into practice not only with archeologists, but also any other occupation that involves digging into the soil. Soil can also be stirred up due to natural disasters such as earthquakes or dust storms.

Those at the risk for developing the most serious aspects of the disease can include those who are pregnant and in their third trimester, African Americans, Asians, and anyone with a weakened immune system, such as those who have HIV or AIDS. Severe pulmonary disease could develop in these individuals in addition to the skin rashes, fever, and other symptoms that are associated with Valley Fever.